Born without fingerprints
Our fingerprints are one of the things that make us unique, individual, identifiable. Yet some people, due to a genetic mutation (adermatoglyphia), are born without them. The condition is so rare that only 4 families worldwide are known to have been affected. Imagine applying for identification documentation or a settlement visa without fingerprints …
For an article on the social and legal implications of not having fingerprints, see this National Geographic article on the subject.